Little and conflicting research has been done on how it affects cortisol levels. Because modafinil stimulates the central nervous system, some research indicates that it may marginally raise cortisol, particularly during times of stress or alertness. Others don’t exhibit any discernible difference. Modalert 200 can improve alertness and lessen fatigue, but it cannot address diseases linked to stress or elevated cortisol levels. It is advisable to discuss any concerns with cortisol imbalance with a healthcare professional in order to receive the proper tests and focused treatment choices.